The Chongmai link: genitalia, sexual function, the nose, vomeronasal organ and pheromones
Gilbert Lambrechts MD
1 bvga@skynet.bePhilip AM Rogers MRCVS
2 philrogers@tinet.ie
1Courseleader of the Belgian Medical Acupuncture Association
2Grange Research Centre, Teagasc, Dunsany, Co. Meath, Ireland
Introduction
If students of acupuncture compare textbooks, they will find that
different authors give different information on the same subject.
Different textbooks show different functions for some points;
some books even differ in their location of the pathways of some
Channels. For example, some books show the pathway of the
Yangweimai to the ear but others show it behind the ear.
Variation between textbooks makes it very difficult for
students to decide which is correct. The basis for these
differences is probably because the original Chinese sources
differ amongst themselves, depending on the year and region of
its origin. In my opinion modern scientific data may help to
answer some of these questions.
The path of the Chongmai (Penetrating, or Thorougfare, or
Strategic Extra-Vessel) in the face is one of these problems.
Some authors mention a branch that travels to the nose; others
say that it ends in the eye. Some say that there is no branch to
the face. Which is correct? The true connections of the Chongmai
have important implications for practitioners.
We will discuss new western research that could explain a
connection between the Chongmai pathway and the nose, via
Jacobson's (the vomeronasal) Organ.
Sources
Examples of the Chongmai pathway are selected from the following
textbooks:
- Anon (Academy for Traditional Chinese Medicine) Précis
dAcupuncture Chinoise, published in China (French
edition).First edition 1977, 328pp. Also, An Outline
of Chinese Acupuncture (Beijing 1975)
- Solinas H, Auteroche B & Mainville (1990 ) Atlas
dAcupuncture Chinoise.First Edition.
Editions Maloine, Paris, 260pp.
- Deadman, Al-Khafaji en Baker (1998 ) A Manual of
Acupuncture.First Edition. Journal of
Chinese Medicine Publications,East Sussex, 667pp.
- Maciocia, Giovanni The Foundations of Chinese
Medecine , First edition ( 1989 ), Churchill
Livingstone, London, 498pp and Obstetrics and
Gynaecology , First edition, 1998, Churchill
Livingstone, London, 959pp.
- Desoutter B ( 1996 ) Merveilleux Vaisseaux,
First edition, Sauramps Editions, Montpellier, 169pp.
- Roustan C. (1978) Traité dacupuncture,
part I, First edition, Masson, Paris,207pp.
- Kespi ( 1982 ) Acupuncture, first edidtion,
Maisonneuve, Moulins-Lès-Metz,785pp.
- OConnor en Bensky ( 1981 ) Acupuncture, a
comprehensive Text. Fifth printing 1987, Eastland
Press, Seattle, 741pp.
- Helms J (1995 ) Acupuncture Energetics.First
edition, Medical Acupuncture Publishers, Berkeley
California, 759pp
- Wiseman N & Ye F (1998) A practical Dictionary
of Chinese Medicine. First Edition. Paradigm
Publications, Brookline Massachussets, 945pp.
Let us look in detail, what these authors show us.
- Précis dacupuncture
Chinoise Chart (Beijing; also An
Outline of Chinese Acupuncture, Beijing, 1975): In
the chart, E = ST; Rn = KI; VC = CV. The text says: at
the level of the umbilicus the abdominal branch splits
and rises bilaterally to the midline, to the throat,
where it encircles the lips. Its main points are
KI11 to KI21.
- Merveilleux
Vaisseaux Chart (Desoutter): In
the chart, Es = ST; Re = KI; RM = CV. Chongmai starts
from ST30-Qichong, with a branch to the leg and one to KI11.This
one follows the KI Channel, with a contact to CV07, to go
to KI27. From here it goes to the mouth to end in the
maxillary sinus ( others say the pharynx).
- Acupuncture
Chart (Kespi): In the chart, E = ST; Rn = KI;
VC = CV. Kespi mentions a branch that comes from KI27 and
circles around the mouth to end in the nasal cavity.
- Traité dacupuncture
Chart (Roustan): In the chart, Est = ST; Rn =
KI; VC = CV. One branch follows the KI Channel and goes
from the thorax to the nasal cavity
- Acupuncture:
A Comprehensive Text Chart (OConnor &
Bensky): In the chart, S = ST; K = KI; Co = CV. The
pathway is the same as that of Roustan. So they mention
also a pathway to the nasal cavity.
- The
Foundations of Chinese Medicine Chart (Maciocia),
and Obstetrics and Gynaecology in Chinese Medicine (Maciocia):
In the chart, Ren = CV. In his book about gynaecology,
Maciocia mentions a branch that ends under the eye. He
does not mention a nasal branch.
- A Manual of
Acupuncture Chart (Deadman, Al-Khafaji & Baker):
In the chart, KID = KI and REN = CV. The Chongmai
rises along the throat, curves around the mouth and ends
under the eye.
- Acupuncture
Energetics Chart (Helms): In the chart, he
uses the standard codes for ST, KI and CV. The pathway
gives a branch that curves around the lips, enters the
nasal cavity and ends in the eye.
- Atlas d'Acupuncture
Chinoise Chart (Solinas, Mainville & Auteroche):
In the chart, E = ST; Rn = KI; VC = CV. The pathway
goes to the upper part of the pharynx and posterior
nasal cavity.
- A practical Dictionary of Chinese Medicine (Wiseman
& Ye 1998): This is probably the most definitive
text on Chinese Medicine written in English. It
mentions 5 paths of the Chongmai: (1) from the
lower abdomen, to the chest and ribs, via the KI channel
and CV08; (2) from the chest, to the throat and face,
skirting the lips and ending in the nose; (3)
from KI11-Henggu (Pubic Bone), to the medial thigh, to
the popliteal fossa (BL40-Weizhong, also called Xuexi-Blood
Cleft [Li 1987]), to the sole of the foot (KI01 area); (4)
from ST30-Qichong (Qi Thoroughfare) to the medial
malleolus, to the big toe; (5) from the main course in
the pelvis, to the spine, which it ascends. In those
details, Wiseman & Ye differ from the 1975 Beijing
text (An Outline of Chinese Acupuncture), which
specifically list only KI points on the Chongmai (KI11 to
KI21).
Discussion
Which pathway on the face is correct?
Although the above authors differ in some other details about the
Vessel pathway, whether or not the Chongmai connects to the nose
is of great importance to clinicians.
Pheromones
Modern scientific data have proven a link between reproductive-genital-sexual
behaviour, the nasal cavity and pheromones. Pheromones are
volatile chemicals, secreted in minute amounts by insects and
animals. Transmitted in air or water, pheromones act as chemical
messengers; they can provoke behavioural or physiological changes
in other animals of the same, or different, species.
Mechanisms of pheromone-signalling: To function effectively,
a pheromone-signalling system needs three parts; it needs a
mechanism:
- to release a chemical impulse, usually from a
glandular organ;
- to transmit the chemical message, usually in air or
water;
- to receive the chemical message, usually via the
olfactory or gustatory organs for smell or taste.
Different types of pheromones
Many types of pheromones have been found in many species of
insects and mammals. There are different categories of pheromones:
- Sex attractants: Secretion of these pheromones
one can stimulate sexual responses and behavioural
changes in the opposite sex
- Alarm pheromones: Secretion of these
pheromones can signal danger so that the recipient
can adopt appropriate defence posture, or try to
escape from the danger.
- Aggregation pheromones: These serve to bring
members of a species together, for example to a food
source
- Dispersion and territorial pheromones: These
are used to mark out a territory for individuals or
groups of a species.
Many pheromones have been isolated from insects and mammals,
and some have been synthesised. They have many uses, for example,
wolf urine to repel smaller mammals, sex-attractants to trap and
control insects (like orchard moths and honeybees), and natural
musk in the productions of perfumes. Research is ongoing on the
use of sex-pheromones in farm animals to aid the detection of
oestrus and ovulation, or even to induce it.
Proof that human pheromones exist
Some studies suggest the existence of human pheromones. In 1971,
Dr Martha McClintock published an article in Nature
about the synchronisation of the menstrual cycle with roommates
of a school ("the dormitory effect"). Pheromones could
be the substances responsible for this observation. It took her
until 1998 to prove that it was a chemical substance secreted by
the sweat glands that influenced the menstrual cycle. In a group
of women the axillary sweat was collected on cotton balls in the
pre-ovulatory phase, the ovulatory phase and in the post-ovulatory
phase. After impregnation with alcohol, to exclude other odours,
a group of subjects were asked to smell from the cotton balls at
regular times. Depending on the time of pheromone presentation in
the pre or postovulatory phase, timing of menstruation
moved significantly forward or backward. She concluded that the
sweat of women contains chemical substances, pheromones, and that
through the olfactory system, they can stimulate another female
to change her menstruation pattern. By showing in a fully
controlled experiment that the timing of ovulation can be
manipulated, this study provides definitive evidence of human
pheromones. (See more details in the Appendix, below).
Which receptors bind pheromones in the nose?
There is heavy evidence that the vomeronasal
organ (also called Jacobsons organ) acts as the
pheromone receptor. It is a little sense organ (part of the
"sixth sense") just beside the cartilage of the nasal
septum and just beside the olfactory nerve. It is only stimulated
by pheromones and not by odours, while the olfactory nerve is
only stimulated by odours and not by pheromones.
The vomeronasal organ, in the floor of the nose of horses and
cattle, is equipped with an olfactory mucous membrane and is
especially developed. Chinese veterinary literature describes
very effective acupoints in the roof of the mouth in cattle at
the opening of its ducts (the nasopalatine ducts). The points are
GV28-01; their indications include bloat, tympany, dyspepsia,
disorders of the neonatal sucking reflex. These points give very
good results in our experience in treating cattle (Dr. Oswald
Kothbauer DVM, Personal communication). Stud male animals (cattle,
sheep, horses) exhibit a behavioural reaction, the flehmen
reaction, in the presence of females in heat. Sensing of sex-pheromone
is said to trigger the reaction. In rats, application of zinc
sulphate, or local anaesthetic to the nasal area prevents them
from sensing pheromones and prevents sexual synchronisation.
Jacobsons
organ
Links of HYPOTHALAMUS ,
OLFACTORY NERVE and VOMERONASAL ORGAN
Relation with Chongmai
Menstruation and Xue-Blood are inseparable; the Chongmai always
is involved in menstrual problems, more then CV. Chongmai, is
known also as Xuehai, Blood-Sea (the same name as SP10-Xuehai).
It regulates all the Twelve Main Channels and its main function
is to regulate menstruation and the distal genitalia, female and
male (Wiseman & Ye 1998). Chongmai governs the Xue, while
Renmai controls the Qi-Energy. Most TCM texts cited here agree
that the Chongmai reaches the head. We suggest that it MUST connect with the nose also.
McClintock's research has proved, pheromones
can influence menstruation through the vomeronasal organ in the
nose. Following this reasoning, we can suggest that all
textbooks should mention this branch of Chongmai to the nose.
That connection is in keeping with the most important function of
the Vessel in treating disorders of the genitourinary and
reproductive systems, and sexuality. In TCM, the Chongmai and
Renmai (CV) cooperate to regulate uterine and reproductive
function. "The KI is the foundation of the native
constitution; the SP provides the material basis of the acquired
constitution; the CV unites all the Yin of the body; the Chongmai
is a sea of the twelve Channels" (Xu 1984). Through the
Chongmai and CV, acupuncture nourishes uterus to adjust the
patient's axis function and recover ovulation. (Mo et al 1993).
One can say that this is of no clinical value,
but in my practice I saw several cases of menstrual problems
together with nasal obstruction, which problems disappeared both
after treating Chongmai by SP04 (Gongsun) and PC06 (Neiguan).
Also, BL40-Xuexi (on the Chongmai) has been used to treat
epistaxis (Li 1987). Also, according to its pathway, pubic
pain relates intimately with injury of Chongmai (Lanza 1984).
Conclusion
Textbooks differ in their descriptions of pathways of some
Channels and Vessels. This makes it difficult for students and
practitioners to choose which one is correct. Modern scientific
data may help to solve these problems. We argue that the function
of the vomeronasal organ in sensing pheromones, the role of
pheromones in sexual expression, the usefulness of the Chongmai
in some nasal conditions, strongly suggest a functional link
between the Chongmai and the nose. We must continue to search for
new data to help to clarify and unify acupuncture theory.
References
- Anon (Academy for Traditional Chinese
Medicine) Précis dAcupuncture Chinoise,
published in China (French edition).First edition 1977,
328pp. Also, An Outline of Chinese Acupuncture (Beijing
1975)
- Solinas H, Auteroche B & Mainville (1990
) Atlas dAcupuncture Chinoise.First Edition.
Editions Maloine, Paris, 260pp.
- Deadman, Al-Khafaji en Baker (1998 ) A
Manual of Acupuncture.First Edition. Journal of
Chinese Medicine Publications,East Sussex, 667pp.
- Maciocia, Giovanni The Foundations of
Chinese Medecine , First edition ( 1989 ), Churchill
Livingstone, London, 498pp and Obstetrics and
Gynaecology , First edition, 1998, Churchill
Livingstone, London, 959pp.
- Desoutter B ( 1996 ) Merveilleux
Vaisseaux, First edition, Sauramps Editions,
Montpellier, 169pp.
- Roustan C. (1978) Traité dacupuncture,
part I, First edition, Masson, Paris,207pp.
- Kespi ( 1982 ) Acupuncture, first
edidtion, Maisonneuve, Moulins-Lès-Metz,785pp.
- OConnor en Bensky ( 1981 ) Acupuncture,
a comprehensive Text. Fifth printing 1987, Eastland
Press, Seattle, 741pp.
- Helms J (1995 ) Acupuncture Energetics.First
edition, Medical Acupuncture Publishers, Berkeley
California, 759pp
- Wiseman N & Ye F (1998) A practical
Dictionary of Chinese Medicine. First Edition.
Paradigm Publications, Brookline Massachussets, 945pp.
- Lanza U (1984) [Importance of
Chongmai (Strategic Vessel) Channel in pubic pain:
Clinical observation of 40 cases of AP in sportsmen].
Rev Fr Med Tradit Chin (105):606-608. Tendon problems in
sportsman may be associated with pubic pain. According to
the course of Chongmai (Strategic Vessel), pubic pain
relates intimately with injury of Chongmai, being
manifest at subjective pain with corresponding sensitive
spots. 40 cases in occupational sportsmen were treated by
EAP + manipulation according to the theory of Chongmai
injury. EAP was used at bilateral SP04, 20 min, 5 Hz, to
tolerance + LI04 + ST30, 70 Hz, weak stimulation. In
earlier sessions, add KI01; later add ST35, KI13, KI04,
GB28, ST03 or LV12, SP12 according to the disease
condition. Paint and slightly press above-mentioned
acupoints and Ashi site with aromatic oil (Juniperus
taiwaniana Hayata, Lavandula angustifolia mill, rosemary
and almond oil). 3. Paint the Ashi site with the oil, and
knead each surrounding muscle and intermuscular membrane
with the four fingers evenly to and fro. Manipulate /
massage the loin and back. 31/40 cases healed in 20-30
days, and 9 cases were responded favourably.
- Li WB (1987) [Clinical uses of BL40].
Shanxi Tradit Chin Med 3(4):44-45. BL40-Weizhong, was
used satisfactorily to treat 5 cases with epistaxis,
enuresis, furuncle, psoriasis and eczema. It is a Shu
point and the He point of the Foot-Taiyang BL Channel, is
also called Xuexi (Blood Xi point). It is used, often by
pricking to bleed it, to Clear the Blood, Drain Heat and
treat acute back sprain. As it is of specific therapeutic
significance, it is also known as the "important
point".
- Mo X; Li D; Pu Y; Xi G; Le X; Fu Z (1993) Clinical
studies on the mechanism for AP stimulation of ovulation.
JTCM Jun 13(2):115-119. Zhejiang Coll of TCM, Hangzhou,
PRC. Ovulatory dysfunction is commonly seen in
gynaecology. It may cause infertility, amenorrhoea,
functional uterine bleeding and a variety of
complications. This research according to TCM theory
records treating with AP 34 patients suffering from
ovulatory dysfunction. Changes in clinical symptoms and
some relative targets are reported, plus findings in
animal experiments. The effect of AP in improving
ovulation and the rationale are discussed. According to
TCM theory concerning the generative and physiologic axis
of women, this research involved the following points: BL18,
BL23, CV04, CV03 and SP06. Reinforcement (Bu Fa) and
reducing (Xie Fa) methods of AP enables it to strengthen
LV and KI. Through the Chongmai and CV Channels
acupuncture nourishes uterus to adjust the patient's axis
function and recover ovulation. Treated circa 30
times, the patients' symptoms improved to varying degrees;
35% were markedly improved and the total effective rate
was 82%. BBT, VS, CMS, and B ultrasonic picture all
improved to some degree. AP may adjust FSH, LH, and E2 in
2 directions and raise the progesterone level, bringing
them to normal. Animal experiments confirmed this result.
AP may adjust endocrine function of the HPOA of women,
thus stimulating ovulation. The results provide some
scientific basis for treating and further studying this
disorder.
- Xu WB (1984) [Treatment of male
infertility by AP]. 2nd Natl Symp Acup-Mox &
Acup-Anesth (Beijing):69-70. Patients with infertility
caused by oligospermia, immobility of spermatozoon or
lengthening the liquefiable time of semen had AP
treatment. In TCM theory, male infertility falls in the
category of heirless. TCM teaches: "The KI is the
foundation of the native constitution; The SP provides
the material basis of the acquired constitution; The CV
unites all the Yin of the body; the Chongmai is a sea of
the twelve Channels". Following those teachings, we
selected points mainly from these Channels: KI06, KI03;
SP06, SP08 and SP09; ST36; CV06, CV04 and BL23, BL52.
These points were divided into two groups, used
alternatively every 1-2 d until d 21. Then after an
interval of 7-10 d, the second course was begun. The
method of lifting, trusting and rotating was used. After
Deqi, the needle was retained for 15-20 min. When
puncturing CV04 and CV06, it is preferable that Deqi is
propagated to the front genitals. After painless
inserting of the needle, lift, thrust and turn it until
Deqi occurred. In some points, such as CV04 and CV06, the
effect would never be marked unless Deqi propagated to
the front genital. Then retain the needle for 15-20 min.
AP gave good results in 8/11 patients (73%).
Appendix:
Key references from Martha McClintocks
Pheromone research [from Pubmed Medline]
- Weizenbaum F, McClintock M, Adler N (1977) Decreases
in vaginal acyclicity of rats when housed with female
hamsters. Horm Behav Jun;8(3):342-7
- McClintock MK (1978) Estrous synchrony and its
mediation by airborne chemical communication (Rattus
norvegicus). Horm Behav Jun;10(3):264-75.
- McClintock MK, Adler NT (1978) Induction
of persistent estrus by airborne chemical communication
among female rats. Horm Behav Dec;11(3):414-8.
- McClintock MK (1984) Estrous synchrony:
modulation of ovarian cycle length by female pheromones.
Physiol Behav May;32(5):701-5. Airborne chemosignals from
different phases of the rat's estrous cycle had opposing
effects on the timing of the estrous cycle which were
consistent with a coupled oscillator model of ovarian
synchrony. Preovulatory odors shortened or phase advanced
the ovarian cycle, whereas ovulatory odors lengthened or
phase delayed the cycle.
- Schank JC, McClintock MK (1992) A coupled-oscillator
model of ovarian-cycle synchrony among female rats.
J Theor Biol Aug 7;157(3):317-62. Committee on the
Conceptual Foundations of Science, University of Chicago,
Illinois 60637. The ovarian cycles of female rats become
synchronized when they live together, as do the cycles of
many other mammals. Ovarian cycles also become
synchronized when rats live apart if they share a common
air supply, indicating that ovarian-cycle synchrony is
mediated by pheromones. We developed a coupled-oscillator
model of ovarian-cycle synchrony to test several
hypotheses about its pheromonal and neuroendocrine
mechanisms and to guide our experimental research. The
model spans three levels of organization: the group, the
rat, and the neuroendocrine components of the ovarian
system. The ovarian system (not the ovaries themselves)
are modeled as an oscillating system. Coupling among
ovarian systems is mediated by the exchange of two
pheromones, one that delays the phase of the ovarian
system and one that advances it. Computer simulation
experiments showed that this coupled-oscillator model can
explain the levels of ovarian-cycle synchrony observed in
groups of female rats while, at the same time, matching
an empirical distribution of ovarian-cycle lengths. By
successfully matching computer simulation data with
empirical data, we were able to infer theoretical
predictions in a number of areas: (1) effect of initial
conditions on the probability that a group will change to
different synchrony level and phase relationships, i.e.
the transition probability between all synchrony levels
and phase relationships; (2) effects of individual
differences in pheromone sensitivity on ovarian-cycle
synchrony; (3) the timing of pheromone sensitivity during
the ovarian cycle; and (4) the existence of partial
luteinizing hormone surges, which may cause the "spontaneous"
prolonged ovarian cycles associated with ovarian-cycle
synchrony. The paper concludes by discussing the
integrative role of this model for experimental research.
In particular, we focus on the role of this model in
interpreting theoretical aspects of ovarian-cycle
synchrony as well as for guiding future experimental
research into its mechanisms and functions.
- Hedricks CA, Ghiglieri M, Church RB, Lefevre J,
McClintock MK (1994) Hormonal and
ecological contributions toward interpersonal intimacy in
couples. Ann N Y Acad Sci Feb 18;709:207-9.
University of Southern California, Los Angeles 90033.
PMID: 8154707, UI: 94205835
- Schank JC, McClintock MK (1997) Ovulatory
pheromone shortens ovarian cycles of female rats living
in olfactory isolation. Physiol Behav Oct;62(4):899-904.
Center for the Integrative Study of Animal Behavior,
Indiana University, Bloomington 47405, USA. jschank@indiana.edu
McClintock found that female rats living in isolation or
in groups synchronized their ovarian cycles, and she
proposed a two-pheromone mechanism to explain synchrony:
one pheromone shortens cycles and the other lengthens
them. Subsequent research revealed that the preovulatory
pheromone shortened cycles, whereas the ovulatory
pheromone lengthened cycles. Schank and McClintock
modeled this mechanism with computer simulation, assuming
variability in sensitivity to pheromones during the
ovarian cycle, and found that a coupled-oscillator
mechanism can synchronize cycles, if pheromone
sensitivity is highest around the time of ovulation. In
this paper, we report the effects of pulses of ovulatory
pheromone on the ovarian cycles of isolated female rats.
Donor females were in the ovulatory phase of their cycle
and recipient females were in olfactory isolation except
during specified phases of their ovarian cycles.
Recipient females showed significant shortening in
ovarian cycles, with no significant variability in
sensitivity to the ovulatory pheromone during the ovarian
cycle. We discuss these conflicting results in terms of
the experimental context of recipient females and the
components and complexities of pheromone signals. PMID:
9284514, UI: 97430213
- McClintock MK (1998) On the nature of
mammalian and human pheromones. Ann N Y Acad
Sci Nov 30;855:390-2. Department of Psychology,
University of Chicago, Illinois 60637, USA. mkm1@midway.uchicago.edu
Communication by chemical (pheromone) signals is
important in many species, including mammals.
Chemosensory and hormonal systems can interact in at
least two ways: (i) chemosensory input, especially but
not exclusively that through the vomeronasal organ, may
elicit hormonal release, which, in turn, may facilitate
behavioral or physiological responses; and (ii) hormones,
especially steroids, may be essential for some responses
to chemosensory, including vomeronasal, input. Recent,
still controversial reports, suggest that chemosensory
communication may occur in humans via a residual
vomeronasal organ and that chemosensory/hormonal
interactions also operate in humans. In this symposium
these matters are examined critically. Johnston explores
the concept of pheromone communication and suggests that
the notion of a single-chemical 'magic bullet'
irresistibly leading to a preprogrammed result is too
simplistic despite documented examples of special stimuli
acting via the vomeronasal organ. Meredith briefly
reviews evidence for hormonal mediation of the effects of
vomeronasal input; including a situation where
vomeronasal and hormonal facilitation of a behavior
appear to be interchangeable--but where vomeronasal input
appears important only in inexperienced animals. Wood
discusses evidence that the effectiveness of chemosensory
input to particular brain nuclei depends critically on
the simultaneous presence of a steroid hormone within the
same nucleus. Monti-Bloch presents his evidence that
steroids may act as gender-specific chemical signals in
humans, exciting an electrical response from the residual
human vomeronasal organ and affecting human hormone
levels. PMID: 9929630, UI: 99128491
- Stern K, McClintock MK (1998) Regulation of
ovulation by human pheromones. Nature Mar 12;392(6672):177-9.
Department of Psychology, The University of Chicago,
Illinois 60637, USA. Pheromones are airborne chemical
signals that are released by an individual into the
environment and which affect the physiology or behaviour
of other members of the same species. The idea that
humans produce pheromones has excited the imagination of
scientists and the public, leading to widespread claims
for their existence, which, however, has remained
unproven. Here we investigate whether humans produce
compounds that regulate a specific neuroendocrine
mechanism in other people without being consciously
detected as odours (thereby fulfilling the classic
definition of a pheromone). We found that odourless
compounds from the armpits of women in the late
follicular phase of their menstrual cycles accelerated
the preovulatory surge of luteinizing hormone of
recipient women and shortened their menstrual cycles.
Axillary (underarm) compounds from the same donors which
were collected later in the menstrual cycle (at ovulation)
had the opposite effect: they delayed the luteinizing-hormone
surge of the recipients and lengthened their menstrual
cycles. By showing in a fully controlled experiment
that the timing of ovulation can be manipulated, this
study provides definitive evidence of human pheromones.