AP and the Cardiovascular System
HEART RHYTHM
Bobrov_VA; Galichanskii IV; Bobrova EV; Mikhalkin IA; Kupnovitskaia IG; Zalesskii VN (1993) The optimization of the anti-arrhythmia effect of kordaron and novocainamide by laser biostimulation therapy in a combined program for treating refractory tachyarrhythmias. Ter Arkh 65(3):62-64. Antiarrhythmic action of He-Ne laser, in combination with novocainamid and kordaron, has been tried in a program on combined treatment of tachyarrhythmia. In refractory patients, He-Ne laser irradiation enhanced the effect of novocainamid, which arrests the paroxysms, and of cordarone, which prevents paroxysms of atrial tachycardia, fibrillation, flutter.
Lovick_TA; Li P; Schenberg LC (1995) Modulation of the cardiovascular defence response by low frequency stimulation of a deep somatic nerve in rats. J Auton Nerv Syst 3 Jan 50(3):347-354. Dept of Physiology, Med Sch, Birmingham, UK. In rats anaesthetised with alphaxalone/alphadolone, electrostimulation in the dorsal part of the PAG produced a pressor response with tachycardia and vasodilatation in the hind limb, a Syndrome known as the "cardiovascular defence reaction" owing to its resemblance to fear-induced haemodynamic changes. After a 20-min period of stimulation of the peroneal nerve at 10 Hz with current intensities sufficient to recruit group II and III fibres the pressor component of the response was significantly reduced compared to control rats. The maximum decrease of the PAG-evoked pressor response was circa 50% (from 32.0+0.7 to 16.6+5.9 mm Hg). The effect lasted for between 60 and 290 min and was not correlated to baseline blood pressure changes observed after the stimulation of the nerve. In contrast, the tachycardia and hind limb vasodilator components of the defence response as well as their baseline values remained unchanged. Resting blood pressure did not change significantly in control rats but showed a small progressive increase in stimulated rats which reached significance 90-100 min after the stimulation. The afferent input from high threshold fibres in a muscle nerve produced a selective and long-lasting depression of the vasoconstrictor components of the midbrain-evoked cardiovascular defence response. This effect is discussed in relation to the long-lasting sympathoinhibitory effects of AP-like stimulation or sustained physical exercise.